Database : HANSEN Search on : ANTIGENOS CD [Subject descriptor] References found : 10 [refine] Displaying: 1 .. 10   in format [Detailed]

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Id: 13727 Author: Cheadle, Eleanor J; Selby, Peter J; Jackson, Andrew M Title: Mycobacterium bovis bacillus Calmette-Guérin-infected dendritic cells potently activate autologous T cells via a B7 and interleukin-12-dependent mechanism ..- Source: s.l; s.n; 2003. 10 p. graf. Abstract: Mycobacteria are potent adjuvants, can survive intracellularly and have been safely used for many years as vaccines against tuberculosis and leprosy. They are thus important potential vectors for recombinant vaccines. Many of their adjuvant properties are mediated following phagocytosis by dendritic cells (DC), which are in turn critical for priming naïve T cells. Although the maturation of DC in response to mycobacteria, such as Mycobacterium bovis bacillus Calmette-Guérin (BCG), is well described the subsequent responses of autologous T cells to mycobacterium-infected DC remains uncharacterized. In our experiments DC infected with BCG expressed more co-stimulatory molecules than tumour-necrosis factor-alpha (TNF-alpha) -treated DC and stimulated more potent mixed leucocyte reactions. When autologous T cells were co-cultured with BCG-exposed DC they became highly activated, as determined by display of CD25, CD54 and CD71 on both CD4+ and CD8+ cells. In contrast, the response of T cells to TNF-alpha-matured DC was significantly less. Cytokine production from T cells cultured with BCG-exposed DC was enhanced with elevated secretion of interleukin-2 (IL-2), IL-10 and interferon-gamma (IFN-gamma) and was produced by both CD4+ and CD8+ lymphocytes as determined by intracellular staining. In particular, IFN-gamma secretion was increased from 50 pg/ml to 25 000 pg/ml and IL-10 secretion increased from 20 pg/ml to 300 pg/ml in BCG-exposed DC co-cultures. Blocking antibodies to B7.1 and B7.2 or IL-12 significantly reduced the secretion of IFN-gamma and reductions were also seen in the expression of CD25 and CD71 by CD4+ cells. These data demonstrate that mycobacterially infected DC are particularly potent activators of autologous T cells compared to TNF-alpha-exposed DC and that the resultant T cells are functionally superior. (AU). Descriptors: ANTIGENOS CD/metab ANTIGENOS CD80/imunol ANTIGENOS DE DIFERENCIACAO DE LINFOCITOS B/metab LINFOCITOS T CD4-POSITIVOS/imunol LINFOCITOS T CD8-POSITIVOS/imunol CITOCINAS/bios CELULAS DENDRITICAS/imunol CELULAS DENDRITICAS/microbiol MOLECULA 1 DE ADESAO INTERCELULAR IMUNOFENOTIPAGEM INTERLEUCINA-12/imunol TRANSFORMACAO LINFOCITICA/imunol MYCOBACTERIUM BOVIS/imunol RECEPTORES DA INTERLEUCINA-2/metab LINFOCITOS T/imunol FATOR DE NECROSE TUMORAL/imunol REGULACAO PARA CIMA/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 08996/s

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Id: 12228 Author: Mustafa, T; Bjune, G; Jonsson, R; Pando, R. H.; Nilsen, R Title: Increased expression of fas ligand in human tuberculosis and leprosy lesions: a potential novel mechanism of immune evasion in mycobacterial infection ..- Source: s.l; s.n; 2001. 10 p. ilus, tab, graf. Descriptors: ANTIGENOS DE BACTÉRIAS ANTIGENOS CD ANTIGENOS CD95 ANTIGENOS DE DIFERENCIAÇAO MIELOMONOCITICA APOPTOSE GRANULOMA DE CORPO ESTRANHO GRANULOMA DE CORPO ESTRANHO IMUNOHISTOQUIMICA LEISHMANIOSE CUTANEA LEISHMANIOSE CUTANEA HANSENIASE HANSENIASE HANSENIASE GLICOPROTEINAS DE MEMBRANAS MODELOS IMUNOLOGICOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS TUBERCULOSE TUBERCULOSE TUBERCULOSE Location: BR191.1; 08711/s

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Id: 11751 Author: Oliver, Stephen J; Kikuch, Toyoko; Krueger, James G; Kaplan, Gilla Title: Thalidomide induces granuloma differentiation in sarcoid skin lesions associated with disease improvement ..- Source: s.l; s.n; 2002. 11 p. ilus, tab, graf. Descriptors: ANTIGENOS CD CÉLULAS DENDRITICAS AGENTES DERMATOLOGICOS AGENTES DERMATOLOGICOS CITOMETRIA DE FLUXO ANTIGENOS HLA-DR IMUNOHISTOQUIMICA IMUNOSSUPRESSORES INTERLEUCINA-12 INTERLEUCINA-2 CÉLULAS DE LANGERHANS SARCOIDOSE SARCOIDOSE SARCOIDOSE DERMATOPATIAS DERMATOPATIAS DERMATOPATIAS LINFOCITOS T TALIDOMIDA TALIDOMIDA RESULTADO DE TRATAMENTO FATOR DE NECROSE DE TUMOR Location: BR191.1; 08523/s

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Id: 11067 Author: Santos, D. O; Santos, S. L; Esquenazi, D; Nery, J. A; Defruyt, M; Lorre, K; van Heuverswyn, H Title: Evaluation of B7-1 (CD80) and B7-2 (CD86) costimulatory molecules and dendritic cells on the immune response in leprosy ..- Source: s.l; s.n; feb. 2001. 10 p. tab, graf. Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE ANTIGENOS CD ANTIGENOS CD80 IMUNIZAÇAO INTERLEUCINA-10 INTERLEUCINA-12 INTERLEUCINA-12 GLICOPROTEINAS DE MEMBRANAS MONOCITOS LINFOCITOS T Location: BR191.1; 07363/s

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Id: 11014 Author: Sharma, Nidhi; Sharma, V. K.; Gupta, Anu; Kaur, Inderjeet; Kaur, Sukhbir; Ganguly, N. K Title: Alterations in early biochemical events following T cell activation in leprosy patients ..- Source: s.l; s.n; 1998. 8 p. tab, graf. Descriptors: HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE ANTIGENOS CD CALCIO MEMBRANA CELULAR GLICOLIPIDIOS FOSFATOS DE POLIISOPRENIL RECEPTORES DA INTERLEUCINA 2 INTERLEUCINA-4 INTERLEUCINA-6 LIQUIDO INTRACELULAR TRANSFORMAÇAO LINFOCITICA TRANSFORMAÇAO LINFOCITICA SUB-POPULAÇOES DE LINFOCITOS T LINFOCITOS T ACETATO DE TETRADECANOILFORBOL Location: BR191.1; 07288/s

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Id: 11001 Author: Schlienger, Katia; Uyemura, Koichi; Jullien, Denis; Sieling, Peter A; Rea, Thomas H; Linsley, Peter S; Modlin, Robert L Title: B7-1, but not CD28, is crucial for the maintenance of the CD4+ T cell responses in human leprosy ..- Source: s.l; s.n; 1998. 7 p. tab, graf. Descriptors: HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE MYCOBACTERIUM LEPRAE ANTICORPOS BLOQUEADORES ANTIGENOS CD ANTIGENOS CD28 ANTIGENOS CD28 ANTIGENOS DE DIFERENCIAÇAO ANTIGENOS CD80 ANTIGENOS CD80 ANTIGENOS CD80 LINFOCITOS T CD4-POSITIVOS LINFOCITOS T CD4-POSITIVOS CÉLULAS CLONAIS SOROS IMUNES LEUCOCITOS MONONUCLEARES TRANSFORMAÇAO LINFOCITICA GLICOPROTEINAS DE MEMBRANAS TRANSDUÇAO DE SINAL PELE PELE Location: BR191.1; 07275/s

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Id: 10145 Author: Colston, M. J Title: The cellular and molecular basis of immunity againts mycobacterial diseases ..- Source: s.l; s.n; 1996. 7 p. ilus. Descriptors: ADJUVANTES IMUNOLOGICOS ANTIGENOS CD VACINA BCG PROTEINAS DE BACTÉRIAS CITOCINAS IMUNIDADE ATIVA IMUNIDADE CELULAR HANSENIASE HANSENIASE LISOSSOMOS MACROFAGOS MYCOBACTERIUM AVIUM MYCOBACTERIUM BOVIS MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS FAGOCITOSE FAGOSSOMOS LINFOCITOS T TUBERCULOSE TUBERCULOSE VACINAS Location: BR191.1; 07119/s

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Id: 10086 Author: Cuevas-Santos, Jesus; Contreras, Felix; McNutt, N. Scott Title: Multibacillary leprosy: lesions with macrophages positive for S100 protein and dendritic cells positive for factor 13a ..- Source: s.l; s.n; 1998. 8 p. ilus, tab. Descriptors: HANSENIASE HANSENIASE HANSENIASE DIMORFA HANSENIASE DIMORFA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE ANTIGENOS CD ANTIGENOS CD1 ANTIGENOS DE DIFERENCIAÇAO ANTIGENOS DE DIFERENCIAÇAO MIELOMONOCITICA PROTEINA-GLUTAMINA GAMA-GLUTAMILTRANSFERASE Location: BR191.1; 07145/s

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Id: 9799 Author: Sieling, P. A; Chatterjee, D; Porcelli, S. A; Prigozy, T. I; Mazzaccaro, R. J; Soriano, T; Bloom, B. R; Brenner, M. B; Kronenberg, M; Brennan, P. J; Modlin, R. L Title: CD1-restricted T cell recognition of microbial lipoglycan antigens ..- Source: s.l; s.n; 1995. 4 p. ilus, graf. Descriptors: MYCOBACTERIUM LEPRAE APRESENTAÇAO DO ANTIGENO CÉLULAS QUE APRESENTAM ANTIGENOS ANTIGENOS CD ANTIGENOS CD1 CONFIGURAÇAO DE CARBOIDRATOS SEQUENCIA DE CARBOIDRATOS LINHAGEM CELULAR INTERFERON TIPO II HANSENIASE LIPOPOLISSACARIDIOS TRANSFORMAÇAO LINFOCITICA DADOS DE SEQUENCIA MOLECULAR FOSFATIDILINOSITOIS RECEPTORES PARA ANTIGENOS DE CÉLULAS T ALFA-BETA ESPECIFICIDADE DE ESPÉCIES LINFOCITOS T CITOTOXICOS Location: BR191.1; 06749/s

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Id: 9367 Author: Fujita, Mayumi; Miyachi, Yoshiki; Izumi, Shinzo; Ishida, Hiroschi; Obara, Akiko; Imamura, Sadao Title: Immunohistochemical study of lepromin reaction in healthy adults ..- Source: s.l; s.n; 1991. 3 p. ilus, tab. Descriptors: ANTIGENOS CD GRANULOMA GRANULOMA IMUNOHISTOQUIMICA ANTIGENO DE MITSUDA PELE PELE PELE FATORES DE TEMPO Location: BR191.1; 06432/s

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